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Palladone (hydromorphone HCl)

On 24-September 2004, the United States Food & Drug Administration (FDA) approved Palladone, a new prescription pain reliever which will provide "around-the-clock" relief to patients with moderate to severe pain. Manufactured by Purdue Pharma L.P. (makers of another powerful pain reliever, OxyContin), Palladone is also an opioid-based drug.

FDA officials stated that Palladone should only be used by patients who are already taking opioid medicines, and who need to take at least 12 milligrams (mg) of the oral hydromorphone (or its equivalent) each day. The extended-release Palladone capsules are available in 12, 16, 24 and 32 mg doses. Additionally they stated that Palladone offers a therapeutic choice for opioid-tolerant patients who might otherwise be candidates for other opioids, and who do not achieve satisfactory therapeutic results with these other products."

More Specific Details About Palladone

The typical adult Palladone dose taken by mouth is 2 mg to 4 mg every four to six hours as required. Rectal suppositories (3 mg) are long-lasting and are especially useful at night. If desired, the oral liquid may be diluted in fruit juice or other beverage.

The typical adult Palladone dose when given by injection is 2 mg given under the skin or into a muscle every four to six hours if necessary. When given by injection in the hospital, your doctor may inject the medication slowly into a vein.

Dosage may also be dependent on other factors (including patient specific details such as weight, past medical conditions, other medications being taken etc.) and only a doctor can recommend these special doses. Patients should never change the way that they take Palladone without first consulting their doctor.

Possible Palladone side effects
As with other prescription drugs, side effects can be predicted or expected to be exactly similar for all individuals. However, a few of the more common and possible Palladone side effects includes nausea, vomiting, dry mouth, dizziness, urinary retention, and constipation. It is possible for side effects other than those listed here to occur. If any side effect(s) seems particularly troublesome or unusual, the patient should speak to a doctor about this as soon as possible.

Who should not take Palladone?
- those with an allergy to narcotic analgesics or to any of the ingredients of the medication
- anyone suffering from acute asthma or other obstructive airway disease
- individuals with acute respiratory depression
- people with severe central nervous system (CNS) depression (i.e., sedation)
- persons with increased intracranial pressure (increased pressure inside the head)
- anyone with pulmonary edema

Also important to note
This medication may be habit-forming. This medicine may also cause drowsiness. If affected, do not consume alcoholic drinks, drive or operate machinery.

Palladone's generic name is hydromorphone and may also go by the brand names Dilaudid, Dilaudid-5 and Hydrostat IR.

Specific Palladone articles and press releases

Palladone Pulled Over Alcohol Risk
FDA Approves Palladone
FDA Approves New Extended Release Pain Medication
Palladone approved for pain relief
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